Korean Journal of Nuclear Medicine Technology (Korean J Nucl Med Technol)

Open access, Peer Reviewed

Indexed in KCI, DOAJ

pISSN 1229-9901
eISSN 2982-8406

Review article

Synthesis of Novel 18F-Labeled-Nitroimidazole-Based Imaging Agents for Hypoxia: Recent Advances

Anh Thu Nguyen1,2 and Hee-Kwon Kim1,2

1Deparment of Nuclear Medicine, Jeonbuk National University, Jeonju, Korea
2Deparment of Medical Science, Jeonbuk National University, Jeonju, Korea

Correspondence to Hee-Kwon Kim. Department of Nuclear Medicine, Jeonbuk National University, 20, Geonji-ro, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54907, Rep. of Korea. Tel :+82-63-250-2768, E-mail : hkkim717@jbnu.ac.kr

Volume 27, Number 2, Article 14, November 2023. Korean J Nucl Med Technol 2023;27(2):14. https://doi.org/10.12972/kjnmt.20230014
Received on July 11, 2022, Revised on July 30, 2023, Accepted on August 01, 2023, Published on November 31, 2023.
Copyright © 2023 Author(s). This is an Open Access article distributed under the terms of the Creative Commons CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hypoxia indicates the condition of low oxygen levels in tissues. In oncology, hypoxia can induce cancer progression and metastasis, as well as cause resistance to cancer therapies. The detection of hypoxia by using molecular imaging, particularly, positron emission tomography (PET) has been extensively studied due to many advantages. Nitroimidazoles, the moieties that can be trapped in hypoxic tissues due to selective reduction, have been used to design and synthesize of hypoxia-targeting radiopharmaceuticals. This review provides a summary of synthetic routes towards 18F-labeled-nitroimidazole radiotracers for PET imaging of hypoxia.
Keywords

Hypoxia, Radiotracers, PET, Nitroimidazole, Tumor

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